Scientists have genetically engineered hookworms to produce therapeutic molecules inside the body, taking a significant step toward using parasites as living drug factories for chronic diseases.
The proof-of-concept study, published in Nature Communications, used CRISPR gene-editing technology to modify human hookworms so they produced an antibody capable of neutralising a deadly toxin. Although still in its early stages, the research raises the possibility that engineered parasites could one day continuously deliver medicines for conditions ranging from autoimmune diseases to obesity, eliminating the need for daily pills or injections.
The work was led by researchers at Washington University School of Medicine in St. Louis, who say a small number of harmless, engineered hookworms could eventually function as an “internal pharmacy.”
“Taking medications every day can be difficult for many patients with chronic illnesses,” said molecular geneticist Dr. Makedonka Mitreva, who led the research. “What if every person at risk of chronic
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